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Joachim Zuther, Lymphedema Specialist. Read more

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Differences between Lipedema and Lymphedema


As outlined in a  previous entry, lipedema is a chronically progressive, symmetrical accumulation of fat in the subcutaneous tissue occurring almost exclusively in women. Primarily the lower extremities are affected, but lipedema may occur in combination with the upper extremities as well. Lipedema is characterized by symmetric enlargement of the limbs, combined with tenderness and easy bruising.

Lipedema is not caused by a disorder of the lymphatic system; however, it is commonly misdiagnosed as bilateral primary lymphedema.

Several marked differences between lipedema and primary lymphedema can be distinguished; these differences are highlighted in the table below.


While lipedema always affects both legs symmetrically (bilateral appearance), primary lymphedema usually affects one leg only. If both legs are involved in primary lymphedema the swelling appears asymmetric (see image on bottom of this article). The feet are not involved in lipedema; the symmetrical distribution of fat is located between the hips and the ankles.
In contrast, the feet in lymphedema are involved in the swelling, and a diagnostic indicator known as the Stemmer sign is positive.
The Stemmer sign is a diagnostic test that involves pinching the skin on the upper surface of the toe (usually second toe) or fingers. If a fold of skin can be pinched and lifted up at the base of the second toe or middle finger, the Stemmer sign is negative. The Stemmer sign is positive and indicative of lymphedema when a skin fold cannot be lifted, but can only be grasped as a lump of tissue. This sign  will become positive if lipedema develops into lipo-lymphedema. Circumstances that can lead to lipedema developing into lymphedema are explained in a previous post.
Tissue in lipedema has a soft rubber-like feel in early stages and may include small fatty lumps (nodules) within the tissues in

Fatty nodules in lipedema

later stages. Pressure with the thumb does not leave an indentation (no pitting) in lipedema. Lymphedema is pitting and the tissue feels firmer that the one in lipedema, especially with fibrotic tissue typically being present starting in stage 2. The cause for the onset of lymphedema are malformations of the lymphatic system, while he underlying cause for the development of lipedema remains unknown; it is thought to be associated with hormonal disorders.



Differences at a Glance


Lipedema Lymphedema
Symmetric (buttocks involved) Not symmetric
Foot not involved Foot involved
Not pitting Pitting edema
Stemmer sign negative Stemmer sign positive
Tissue feels rubbery Tissue feels firmer (starting stage 2 lymphedema)
Painful to touch Generally not painful to touch
Easy bruising Generally not bruising
Hormonal disturbances frequent Generally no hormonal disturbance

Stemmer sign; positive on left


Primary bilateral lymphedema

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3 comments to Differences between Lipedema and Lymphedema

  • Pat

    Another great page of info. Thanks!!!! To treat correctly it is critical to understand the two conditions, how they are and/or are not related. It is also terribly important for those with lipedema to understand this is NOT a weight issue in the sense that you can NOT diet your way out of lipedema. The Lymphedema Blog is definitely on my list of favorite sites both in terms of topics, your willingness to reach out to patients and then in the use of evidence based medicine.

  • Mary Beth

    There is also an extremely rare condition called Dercum’s Disease which presents with extremely painful fatty nodules and can include swelling. Some of these patients have been misdiagnosed as lipedema or lipolymphedema. I have treated one patient with it who found relief with MLD (although initially with nausea) and has found even greater relief with daily use of Flexitouch.

  • Is there any cure or treatment for lypedema?

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